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Abstract
Abstract
According to WHO data (2020), individuals with inadequate physical exercise develop a mortality risk of 20-30% compared to individuals with adequate physical exercise. Regular physical exercise has a positive impact in maintaining a healthy lifestyle, whereas acute intense physical exercise such as in untrained individuals can have a negative impact through the occurrence of oxidative stress. Physical exercise with repetition of exercise can form an adaptation mechanism thereby increasing the work of endogenous antioxidants and inhibiting the formation of ROS. Meanwhile, acute physical exercise without repetition of exercise can cause a decrease in endogenous antioxidant levels and an increase in ROS. Increased ROS induces oxidative stress, which then plays a role in liver damage. This study aims to determine the effect of submaximal physical exercise frequency on SGPT levels, an indicator of liver damage. This research was a laboratory experimental study with a post-test only control group design using 27 Wistar female white rats which were divided into 3 groups; K1 was given standard feed for 4 weeks, K2 was given standard feed for 4 weeks, submaximal physical exercise on days 1 to 14 and 21 of the study, and K3 was given standard feed for 4 weeks and submaximal physical exercise on day 21 of the study. After intervention, all groups of rats were taken for blood to calculate SGPT levels and then the results of the data were analyzed statistically. The results of the Kruskal-Wallis test showed a significance of 0.479 (p>α) with α=0.05, which means that there was no significant difference in the frequency of submaximal physical exercise on SGPT levels in female Wistar rats (Rattus norvegicus). The conclusion of this study showed that there was no effect of the frequency of submaximal physical exercise on SGPT levels in female Wistar rats (Rattus norvegicus).
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References
2. Yuniarti E. Pengaruh Latihan Submaksimal Terhadap Kadar Interleukin-6 Pada Siswa Pusat Pendidikan Latihan Pelajar Sumatera Barat. J Sainstek. 2014;6(2):189–92.
3. Lesmana HS, Broto EP. Profil Glukosa Darah Sebelum, Setelah Latihan Fisik Submaksimal dan Selelah Fase Pemulihan Pada Mahasiswa FIK UNP. Media Ilmu Keolahragaan Indones [Internet]. 2019 Jan 4 [cited 2022 Jul 16];8(2):44–8. Available from: https://journal.unnes.ac.id/nju/index.php/miki/article/view/12726
4. Ruhee RT, Ma S, Suzuki K. Protective Effects of Sulforaphane on Exercise-Induced Organ Damage via Inducing Antioxidant Defense Responses. Antioxidants (Basel, Switzerland) [Internet]. 2020 Feb 1 [cited 2022 Jun 19];9(2). Available from: https://pubmed.ncbi.nlm.nih.gov/32033211/
5. Torkamaneh S, Sharifi G, Rafieian-Kopaei M. The comparison between effects of Berberis vulgaris Extract and aerobic exercise on none-alcoholic fatty liver in male rat. Der Pharma Chem. 2016;8(1):244–7.
6. Rezzani R, Franco C. Liver, Oxidative Stress and Metabolic Syndromes. Nutrients [Internet]. 2021 Feb 1 [cited 2022 Jun 12];13(2):1–4. Available from: https://pubmed.ncbi.nlm.nih.gov/33494242/
7. WHO. Physical activity [Internet]. World Health Organization. 2020 [cited 2022 Jul 23]. Available from: https://www.who.int/news-room/fact-sheets/detail/physical-activity
8. Macintyre TE, Lamego MK, Mandolesi L, Polverino A, Montuori S, Foti F, et al. Effects of Physical Exercise on Cognitive Functioning and Wellbeing: Biological and Psychological Benefits. Front Psychol | www.frontiersin.org [Internet]. 2018;1:509. Available from: www.frontiersin.org
9. Andini A, Indra EN. 10071-29617-1-Pb. Medikapora. 2016;50:39–52.
10. Barcelos RP, Royes LFF, Gonzalez-Gallego J, Bresciani G. Oxidative stress and inflammation: liver responses and adaptations to acute and regular exercise. Free Radic Res. 2017;51(2):222–36.
11. Pizzino G, Irrera N, Cucinotta M, Pallio G, Mannino F, Arcoraci V, et al. Oxidative Stress: Harms and Benefits for Human Health. Oxid Med Cell Longev [Internet]. 2017 [cited 2022 Jun 12];2017. Available from: /pmc/articles/PMC5551541/
12. Muriel P, Gordillo KR. Editorial Role of Oxidative Stress in Liver Health and Disease. 2016; Available from: http://dx.doi.org/10.1155/2016/9037051
13. Li S, Tan H-Y, Wang N, Zhang Z-J, Lao L, Wong C-W, et al. The Role of Oxidative Stress and Antioxidants in Liver Diseases. 2015; Available from: www.mdpi.com/journal/ijms
14. Kasper DL, Fauci AS, Hauser SL, Longo DL, Larry JJ, Loscalzo J. Harrison’s Gastroenterology and Hepatology. 19th edn. 2017.
15. Hasan KMM, Tamanna N, Haque MA. Biochemical and histopathological profiling of Wistar rat treated with Brassica napus as a supplementary feed. Food Sci Hum Wellness. 2018 Mar 1;7(1):77–82.
16. Wicaksana KL. GAMBARAN KADAR SGPT ( SERUM GLUTAMIC PYRUVIC TRANSAMINASE ) PADA PEROKOK AKTIF DI USIA 17 - 25 TAHUN DENGAN LAMA MEROKOK < 10 TAHUN. 2019;
17. Hammouda O, Chtourou H, Chaouachi A, Chahed H, Ferchichi S, Kallel C, et al. Effect of Short-Term Maximal Exercise on Biochemical Markers of Muscle Damage, Total Antioxidant Status, and Homocysteine Levels in Football Players. Asian J Sports Med [Internet]. 2012 [cited 2022 Nov 22];3(4):239. Available from: /pmc/articles/PMC3525820/
18. Risfandi M, Harahap NS, Nailuvar R, Sinaga FA. Liver Function Test Elevation in Moderate Intensity Physical Exercise. 2019;
19. Bijeh N, Rashidlamir A, Hejazi K. The Effect of Eight Weeks Swimming Training on Hepatic Enzymes and Hematological Values in Young Female. 2013;(May 2014).
20. Gao Y, Lu J, Liu X, Liu J, Ma Q, Shi Y, et al. Effect of Long-Term Exercise on Liver Lipid Metabolism in Chinese Patients With NAFLD: A Systematic Review and Meta-Analysis. Front Physiol. 2021 Nov 22;12:1892.
21. Carpentieri A, Gamberi T, Modesti A, Amoresano A, Colombini B, Bagni MA, et al. Profiling carbonylated proteins in heart and skeletal muscle mitochondria from trained and untrained mice. J Proteome Res. 2016;
22. Purnomo M. Asam Laktat dan Aktivitas SOD Eritrosit pada Fase Pemulihan Setelah Latihan Submaksimal. Media Ilmu Keolahragaan Indones [Internet]. 2012 May 23 [cited 2022 Dec 3];1(2). Available from: https://journal.unnes.ac.id/nju/index.php/miki/article/view/2031
23. Medeiros N, Da F, Gaúcha S, Boeno F, Ramis TR, Da N, et al. Effects of Acute Exercise with Blood Flow Restriction on Oxidative Stress Biomarkers. Int J Sport Sci [Internet]. 2017 [cited 2022 Dec 3];2017(5):191–5. Available from: https://www.researchgate.net/publication/320396603
24. Smart NA, King N, Mcfarlane JR, Graham PL, Dieberg G. Effect of exercise training on liver function in adults who are overweight or exhibit fatty liver disease: a systematic review and meta-analysis. Br J Sports Med [Internet]. 2018 [cited 2022 Nov 30];(52). Available from: http://bjsm.bmj.com/
25. Delicata N-P, Delicata J, Delicata L-A. Strenuous Exercise—An Unusual Cause of Deranged Liver Enzymes. Case Reports Clin Med [Internet]. 2018 Mar 6 [cited 2022 Dec 1];7(3):177–81. Available from: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=82862
26. Fajariyah S, Utami ET, Arisandi Y, Biologi J, Universitas F. Efek Pemberian Estrogen Sintetis ( Diethylstillbestrol ) terhadap Struktur Hepar dan Kadar SGOT dan SGPT pada Mencit ( Mus musculus ) Betina Strain Balb ’ C The Effect of Synthetic Estrogen on Hepar Stucture And Level of SGOT and SGPT of Balb ’ C Female M. J Ilmu Dasar. 2010;11(Gmikro):76–82.