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Abstract
Latar Belakang: Kanker serviks menempeti peringkat 4 didunia dan merupakan penyakit yang memiliki angka mortalitas yang tinggi sekitar 275 ribu kematian di dunia pada tahun 2019. Di Indonesia dalam kurun waktu 5 tahun terakhir kanker serviks menempati urutan peringkat kedua kasus kanker terbanyakpada wanita setelah kanker payudara dengan jumlah kasus baru sebanyak 36.633 dan angka kematian mencapai 21.003 jiwa.
Tujuan: Penelitian ini memiliki tujuan untuk mengetahui karakteristik dan gambaran histopatologi Ca serviks di RSPAL Dr. Ramelan Surabaya periode Januari 2019 hingga Desember 2021.
Metode Penelitian: Penelitian ini merupakan penelitian deskriptif yang menggunakan metode non-probability sampling dengan jenis purposive sampling dari data sekunder rekam medis pasien kanker serviks di RSPAL Dr. Ramelan Surabaya.
Hasil: Hasil penelitian menunjukkan bahwa dari 130 sampel terdapat beberapa karakteristik penderita kanker serviks, yaitu yang tertinggi berasal dari kelompok usia 40-60 tahun sebesar 66,92%, gambaran histopatologi squamous cell carcinoma sebesar 70,77%, stadium IIIB sebesar 85,38% dan penatalaksanaan kemoradiasi sebesar 69,23%.
Kesimpulan: Jenis kanker serviks berdasarkan histopatologi yang paling sering dijumpai adalah kanker serviks squamous cell carcinoma
Article Details
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References
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– IIIB dengan Terapi Radiasi dan Kemoradiasi di Rumah Sakit Umum Pusat Dr
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26. Lichter KE, Levinson K, Hammer A, Lippitt MH, Rositch AF. Gynecologic Oncology Understanding cervical cancer after the age of routine screening : Characteristics of cases , treatment , and survival in the United States. Gynecol Oncol [Internet]. 2022;165(1):67–74. Available from: https://doi.org/10.1016/j.ygyno.2022.01.017
27. Musunuru HB, Pifer PM, Mohindra P, Albuquerque K, Beriwal S. Advances in management
2. Olusola P, Banerjee HN, Philley J V., Dasgupta S. Human Papilloma Virus- Associated Cervical Cancer and Health Disparities. Cells. 2019 Jun 21;8(6):622.
3. The Global Cancer Observatory. Cancer Incident in Indonesia [Internet]. Vol. 858, International Agency for Research on Cancer. 2020. Available from: https://gco.iarc.fr/today/data/factsheets/popul ations/360-indonesia-fact-sheets.pdf
4. Ryndock EJ, Meyers C. A risk for non- sexual transmission of human papillomavirus? Expert Rev Anti Infect Ther. 2014;12(10):1165–70.
5. La Rosa G. Papillomavirus. In: Meschke JS, Girones R, editors. Water and Sanitation for the 21st Century: Health and Microbiological Aspects of Excreta and Wastewater Management (Global Water Pathogen Project) [Internet]. Michigan State University; 2019. p. 3–10. Available from: https://www.waterpathogens.org/book/papill omavirus
6. Stumbar SE, Stevens M, Feld Z. Cervical Cancer and Its Precursors: A Preventative Approach to Screening, Diagnosis, and Management. Prim Care - Clin Off Pract [Internet]. 2019;46(1):117–34. Available from:
https://doi.org/10.1016/j.pop.2018.10.011
7. Tsikouras P, Zervoudis S, Manav B, Tomara E, Iatrakis G, Romanidis C, et al. Cervical cancer: Screening, diagnosis and staging. J BUON. 2016;21(2):320–5.
8. Levine DA, Gaillard SL, Lin LL, Chi
DS, Berchuck A, Dizon DS, et al. Handbook for Principles and Practice of Gynecologic Oncology. 3rd ed. Lippincott Williams & Wilkins (LWW); 2020. 165–166 p.
9. CDC. Cervical Cancer Rates Have Dropped Among Young Women in the United States | CDC [Internet]. 2021 [cited 2023 Jan 30]. Available from: https://www.cdc.gov/cancer/dcpc/research/ar ticles/cervical-cancer-rates-young- women.htm#print
10. Subramaniam S, Sumadi IWJ, Dewi IGASM. Clinicopathological patterns of cervical carcinoma in pathological anatomy laboratory at RSUP Sanglah Denpasar, Bali since 2012-2016. Intisari Sains Medis [Internet]. 2020 Mar 26;11(1):259–62. Available from:
https://isainsmedis.id/index.php/ism/article/vi ew/210
11. Narayan S, Sharma N, Kapoor A, Sharma R, Kumar N, Singhal M, et al. Pros and Cons of Adding of Neoadjuvant Chemotherapy to Standard Concurrent Chemoradiotherapy in Cervical Cancer: A Regional Cancer Center Experience. J Obstet Gynecol India. 2016 Oct 11;66(5):385–90.
12. Herlana F, Nur IM, Purbaningsih W. Karakteristik pasien kanker serviks berdasar atas usia , paritas , dan gambaran histopatologi di RSUD Al-ihsan bandung characteristics of cervical cancer patients base on age , parity , and histopathologic pattern in Al-ihsan Bandung regional hospital. Bandung Meet Glob Med Heal. 2017;1(22):138–42.
13. Rozi AF, Susanti D, Annas JY. Karakteristik Pasien Kanker Serviks di RSUD Dr. Soetomo Surabaya Periode Januari - Desember 2017. 2017;392:22–3.
14. Jackaman C, Tomay F, Duong L, Abdol Razak NB, Pixley FJ, Metharom P, et al. Aging and cancer: The role of macrophages and neutrophils. Ageing Res Rev [Internet]. 2017;36:105–16. Available from: http://dx.doi.org/10.1016/j.arr.2017.03.008
15. Zhou H, Li Q, Xu C, Liang H, Wang Y, Duan Y, et al. Prognosis of stage III cervical cancer: A two-way outcome study. Transl Cancer Res. 2020;9(4):2565–75.
16. WANG J, WANG T, YANG YY, CHAI YL, SHI F, LIU Z. Patient age, tumor appearance and tumor size are risk factors for early recurrence of cervical cancer. Mol Clin Oncol. 2015;3(2):363–6.
17. Güzel C, van Sten-van’t Hoff J, de Kok IMCM, Govorukhina NI, Boychenko A,
Luider TM, et al. Molecular markers for cervical cancer screening. Expert Rev Proteomics [Internet]. 2021 Aug 3;18(8):675–
91. Available from: https://www.tandfonline.com/doi/full/10.108 0/14789450.2021.1980387
18. Laengsri V, Kerdpin U, Plabplueng C, Treeratanapiboon L, Nuchnoi P. Cervical Cancer Markers: Epigenetics and microRNAs. Lab Med. 2018;49(2):97–111.
19. Oktaviani BD, Sriwidyani NP, Sumadi JIW. Karakteristik klinikopatologi penderita kanker serviks uteri berdasarkan data di laboratorium patologi anatomi RSUP Sanglah Denpasar tahun 2011-2015. E-Jurnal Med. 2018;7(8):1–6.
20. Meng Y, Chu T, Lin S, Wu P, Zhi W, Peng T, et al. Clinicopathological characteristics and prognosis of cervical cancer with different histological types: A population-based cohort study. Gynecol Oncol [Internet]. 2021;163(3):545–51. Available from:
https://doi.org/10.1016/j.ygyno.2021.10.007
21. Marina S, Rizki H, Sidharti L, Windarti I. Karakteristik Klinikopatologi Penderita Kanker Serviks di RSUD Dr. H. Abdul Moloek Tahun 2018 - 2021. J Kesehat dan Agromedicine. 2021;8(1).
22. Soslow RA, Park KJ, Stolnicu S. Atlas of Diagnostic Pathology of the Cervix [Internet]. 1st ed. Soslow RA, Park KJ, Stolnicu S, editors. Atlas of Diagnostic Pathology of the Cervix. Cham: Springer International Publishing; 2021. 352 p. Available from:
http://link.springer.com/10.1007/978-3-030- 49954-9
23. Sumarmi S, Hsu YY, Cheng YM, Lee SH. Factors associated with the intention to undergo Pap smear testing in the rural areas of Indonesia: a health belief model. Reprod Health [Internet]. 2021;18(1):1–10. Available from: https://doi.org/10.1186/s12978-021- 01188-7
24. Khatimah GH, Muhammad S. Hubungan Tipe Histopatologi Dengan Respon Kemoterapi Neoadjuvant Pada Kanker Serviks Stadium IB2 dan IIA2. Andalas Obstet Gynecol. 2019;3(2):63–81.
25. Legianawati D, Puspitasari IM, Suwantika AA, Kusumadjati A. Profil Penatalaksanaan Kanker Serviks Stadium IIB
– IIIB dengan Terapi Radiasi dan Kemoradiasi di Rumah Sakit Umum Pusat Dr
. Hasan Sadikin Bandung Periode Tahun 2015
– 2017 Management Profile of Stage IIB – IIIB Cervical Cancer with Radiation Therapy and. J Farm Klin Indones. 2019;8(3).
26. Lichter KE, Levinson K, Hammer A, Lippitt MH, Rositch AF. Gynecologic Oncology Understanding cervical cancer after the age of routine screening : Characteristics of cases , treatment , and survival in the United States. Gynecol Oncol [Internet]. 2022;165(1):67–74. Available from: https://doi.org/10.1016/j.ygyno.2022.01.017
27. Musunuru HB, Pifer PM, Mohindra P, Albuquerque K, Beriwal S. Advances in management